Gastrointestinal (GI): NSAIDs that block COX-one activity have correlations with GI difficulties as a result of inhibition of the synthesis of gastroprotective agents which include PGE2 and also other prostaglandins. This inhibition results in reduced mucin creation by gastric epithelial cells, much less bicarbonate secretion, and less epithelial cell turnover, https://tonyi479zaa3.wikiconverse.com/user