Chemotherapy was potentiated by E7449 and one agent experienced substantial antitumor action in BRCA-deficient xenografts. Also, E7449 inhibited Wnt/β-catenin signaling in colon cancer mobile strains, possible through TNKS inhibition. In step with this possibility, E7449 stabilized axin and TNKS proteins resulting in β-catenin de-stabilization and substantially altered expression of Wnt https://johnj565hzr7.theobloggers.com/profile