Existence-threatening respiratory melancholy and Dying have transpired in small children who been given codeine. Most of the noted cases transpired next tonsillectomy and/or adenoidectomy and a lot of of the children had evidence of getting extremely-quick metabolizers of codeine due to a cytochrome P450 (CYP) 2D6 polymorphism (see WARNINGS, PRECAUTIONS; https://wockusa.com/product/pai-promethazine-vc-with-codeine-oral-solution/