Metabolic alterations connected to T2D are well characterised by epidemiological and research primarily based experiments. The pathogenesis and progression of T2D is ascribed to four mechanisms; increased Sophisticated glycation conclude product or service (AGE) formation, greater polyol pathway flux, activation of protein kinase C (PKC) isoforms, and increased hexosamine pathway https://www.directivepublications.org/journal-of-diabetology-research/