Male laboratory animals who were given remedies much like bosentan designed issues with their testicles and produced less sperm (male reproductive cells) than usual. Bosentan is a specific and aggressive antagonist at endothelin receptor types ETA and ETB. Bosentan has a slightly increased affinity for ETA receptors than for ETB https://bosentan81245.snack-blog.com/25989932/not-known-factual-statements-about-bosentan