By way of example, extreme activation of CaMKII is usually characterised by enhanced activity of Ca2+ channel gating, leakage of Ca2+ from sarcoplasmic reticulum, and dysregulation of Ca2+ homeostasis, which may with each other result in arrhythmia and coronary heart failure. Hashimoto et al. -indazole derivatives with disubstituent groups at https://indazoleproducts76420.aioblogs.com/84816009/about-indazole-synthesis-review